{"id":987533979,"date":"2024-07-14T01:01:55","date_gmt":"2024-07-14T05:01:55","guid":{"rendered":"https:\/\/danellaconsulting.net\/?p=987533979"},"modified":"2024-07-14T16:11:22","modified_gmt":"2024-07-14T20:11:22","slug":"ivermectin-no-wonder-the-two-who-discovered-it-won-a-nobel-prize","status":"publish","type":"post","link":"https:\/\/danellaconsulting.net\/index.php\/2024\/07\/14\/ivermectin-no-wonder-the-two-who-discovered-it-won-a-nobel-prize\/","title":{"rendered":"Ivermectin, No Wonder the Two who Discovered it won a NOBEL PRIZE"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<blockquote class=\"twitter-tweet\" data-media-max-width=\"560\">\n<p dir=\"ltr\" lang=\"en\">Ivermectin?. No wonder the two gentlemen who discovered it won a NOBEL PRIZE! This drug DOES WAY MORE THAN THEY ARE TELLING US?! I double dare you to watch this because it will BLOW YOU AWAY?<br \/>\n<a href=\"https:\/\/t.co\/WOY1id6Hrh\">pic.twitter.com\/WOY1id6Hrh<\/a><\/p>\n<p>\u2014 Bobby D? (@robertdunlap947) <a href=\"https:\/\/twitter.com\/robertdunlap947\/status\/1812066142594220126?ref_src=twsrc%5Etfw\">July 13, 2024<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><br \/>\n[\/et_pb_text][et_pb_text _builder_version=&#8221;4.25.2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h2 style=\"text-align: center;\">An Ivermectin Influencer Died. Now His Followers Are Worried About Their Own \u2018Severe\u2019 Symptoms.<\/h2>\n<p>Source: https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/<\/p>\n<article id=\"post-2801\" class=\"post-2801 post type-post status-publish format-standard has-post-thumbnail hentry category-misinformation-disinformation-and-conspiracy-theories\">\n<div class=\"entry-content\">\n<div class=\"inset\">\n<div class=\"inset__container\">\n<p>(<a href=\"https:\/\/www.vice.com\/en\/article\/z3mb89\/ivermectin-danny-lemoi-death\">Vice<\/a>) Danny Lemoi took a daily dose of veterinary-grade ivermectin and told his thousands of followers to give the drug to children. He died of a common side effect of the medication.<\/p>\n<p>Just before 7 am on March 3, Danny Lemoi posted an update in his hugely popular pro-ivermectin Telegram group, Dirt Road Discussions: \u201cHAPPY FRIDAY ALL YOU POISONOUS HORSE PASTE EATING SURVIVORS !!!\u201d<\/p>\n<p>Hours later, Lemoi was dead.<\/p>\n<p>For the last decade, Lemoi had taken a daily dose of veterinary ivermectin, a dewormer designed to be used on large animals like horses and cows. In 2021, as ivermectin became a popular alternative COVID-19 treatment among anti-vaxxers, he launched what became one of the largest Telegram channels dedicated to promoting the use of it, including instructions on how to administer ivermectin to children.<\/p>\n<p>But despite Lemoi\u2019s death, the administrators of his channel are pushing his misinformation\u2014even as his followers share their own worrying possible side effects from taking ivermectin and some question the safety of the drug.\u00a0\u00a0<\/p>\n<p>Lemoi, a heavy equipment operator who lived in Foster, Rhode Island, \u201cpassed away unexpectedly\u201d on March 3, according to an\u00a0<a href=\"https:\/\/www.galloglyfuneralhome.com\/obituary\/Daniel-Lemoi\" target=\"_blank\" rel=\"noreferrer noopener\">online obituary post by his family last week<\/a>. He was survived by his parents and brother. The obituary gave no details about the cause of his death.<\/p>\n<p>In the Telegram channel, administrators broke the news of his death to his followers. \u201cThough it was obvious that Danny had the biggest heart, it was unbeknownst to him that his heart was quite literally overworking and overgrowing beyond its capacity, nearly doubled in size from what it should have been,\u201d the admins wrote, adding: \u201cWe understand that this is going to raise questions for those who were following him.\u201d<\/p>\n<p>The admins added that Lemoi had undergone testing on his heart last year, but the results had shown no cause for concern.<\/p>\n<p>Lemoi began taking the version of ivermectin designed for animals on a daily basis in 2012, after he was diagnosed with Lyme disease, according to a detailed account of his medical history he gave on a podcast last November. He said then that five months after first taking the drug, he quit all other treatments and believed ivermectin had \u201cregenerated\u201d his heart muscle.\u00a0<\/p>\n<p>During the pandemic, Ivermectin became hugely popular among anti-vaxxers, many of whom were taking and recommending the veterinary formulation of the drug, rather than the one designed for human use. While ivermectin for humans is used to treat serious illnesses like river blindness, it has repeatedly been shown to\u00a0<a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">be an ineffective treatment for COVID-19<\/a>.<\/p>\n<p>And according to the Missouri Poison Center, ingesting large doses of ivermectin formulated for animals has a long list of side effects, including\u00a0<a href=\"https:\/\/missouripoisoncenter.org\/facts-about-ivermectin\/\" target=\"_blank\" rel=\"noreferrer noopener\">seizures, coma, lung issues, and heart problems<\/a>. Veterinary ivermectin is not a cure or effective treatment for COVID,\u00a0<a href=\"https:\/\/www.vice.com\/en\/article\/88nzn3\/the-fda-was-internally-thrilled-over-that-viral-horse-paste-tweet\">the FDA has repeatedly warned<\/a>, and is highly concentrated because it is designed for large animals like horses and cows. \u201cSuch high doses can be highly toxic in humans,\u201d\u00a0<a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">the FDA cautions<\/a>.<\/p>\n<p>\u201cDanny was fully convinced that his heart had regenerated after his incident with Lyme disease that almost ended in congestive heart failure,\u201d the admins wrote, before claiming that \u201ca family history of heart disease and chronic stress\u201d were why his heart had ultimately become engorged. \u201cAll of his other organs were unremarkable,\u201d the admins wrote. \u201cAnd this was determined to be a death by unfortunate natural causes.\u201d\u00a0<\/p>\n<p>The admins of Lemoi\u2019s channel did not respond to VICE News\u2019 questions about where they got their information about his death. Lemoi\u2019s surviving family did not respond to VICE News\u2019 request for comment on the cause of his death.<\/p>\n<p>But a review of Lemoi\u2019s Telegram channels shows that many of his followers who are taking his dosage recommendations, or \u201cprotocols,\u201d for veterinary ivermectin are experiencing numerous known side effects of taking the drug.<\/p>\n<p>\u201cI\u2019m 4 months now and all hell\u2019s breaking loose, all pain has hit my waist down with sciatic, shin splints, restless leg syndrome, tight sore calves &amp; it feels like some pain in the bones,\u201d a member wrote on Friday.<\/p>\n<p>Lemoi explained away the negative side effects of taking veterinary ivermectin by describing them as \u201cherxing,\u201d a real term to describe an adverse response that occurs in people who take antibiotics as a treatment for Lyme disease.<\/p>\n<p>\u201cMy wife has been taking ivermectin for 3 months,\u201d a member wrote Friday. \u201cShe is being treated for autoimmune hepatitis, thyroid, and vertebrae issues. She has had some serious HERXING. Today she has a migraine, vomiting and severe stomach pain. Does anyone have any ideas how to help, and are these HERXING symptoms?\u201d<\/p>\n<p>Some members of the group are taking ivermectin not only as a treatment against COVID, but as a cure-all for almost every disease\u2014from cancer and depression, to autism and ovarian cysts\u2014believing that every disease is caused by a parasite that is removed from the body by ivermectin, just as animals are given the drug to treat parasitic worms like tapeworm.\u00a0\u00a0Lemoi also formulated an ivermectin regimen for children, and numerous members of the group reported that they were using it. This week alone one member wrote that she had established another group for \u201cparents of children on the spectrum, cerebral palsy, pans\/panda, downs etc.,\u201d who are using the Lemoi\u2019s recommended children\u2019s dosage.\u00a0\u00a0<\/p>\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2803\" src=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.57.49-836x1024.png\" sizes=\"(max-width: 836px) 100vw, 836px\" srcset=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.57.49-836x1024.png 836w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.57.49-245x300.png 245w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.57.49-768x941.png 768w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.57.49.png 1200w\" alt=\"\" width=\"836\" height=\"1024\" \/><\/figure>\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2804\" src=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.58.04-1005x1024.png\" sizes=\"(max-width: 1005px) 100vw, 1005px\" srcset=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.58.04-1005x1024.png 1005w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.58.04-294x300.png 294w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.58.04-768x783.png 768w, https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/03\/Screenshot-2023-03-14-at-08.58.04.png 1158w\" alt=\"\" width=\"1005\" height=\"1024\" \/><\/figure>\n<p>When some members of the group blamed Lemoi\u2019s death on ivermectin, they were criticized in the Telegram channel; their fellow group members claimed they were spreading misinformation.<\/p>\n<p>\u200b\u200b\u201cNo one can convince me that he died because of ivermectin,\u201d one member wrote this week. \u201cHe ultimately died because of our failed western medicine which only cares about profits and not the cure.\u201d<\/p>\n<p>Despite Lemoi\u2019s death, administrators said this week the Telegram channel would live on, and the group is attracting new members who continue to take ivermectin despite suffering serious side effects.<\/p>\n<p>\u201cI am very new to this\u2026 I\u2019ve been on Bimectin paste for 20 days,\u201d one new member wrote on Friday morning, explaining that he too was suffering from Lyme disease. \u201cI have severe chest pain. Costochondritis symptoms. Air hunger, internal tremors, brain fog, headaches on the back of my head, anxiety, depression, doom and gloominess.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<footer class=\"entry-footer default-max-width\"><\/footer>\n<\/article>\n<div class=\"panel comment-panel\">\n<div class=\"panel__container\">\n<div class=\"panel__main\">\n<div id=\"comments\" class=\"comments-area default-max-width show-avatars\">\n<h2 class=\"comments-title\">7 comments<\/h2>\n<ol class=\"comment-list\">\n<li id=\"comment-539\" class=\"comment even thread-even depth-1\">\n<div id=\"div-comment-539\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img loading=\"lazy\" decoding=\"async\" class=\"avatar avatar-60 photo\" src=\"https:\/\/secure.gravatar.com\/avatar\/9c82c56e5f41c7187f0a38b0f509b421?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/9c82c56e5f41c7187f0a38b0f509b421?s=120&amp;d=mm&amp;r=g 2x\" alt=\"\" width=\"60\" height=\"60\" \/><cite class=\"fn\">Kathryn Rene&#8217; Griffin<\/cite>\u00a0<span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-539\">July 5, 2023 at 2:33 pm<\/a><\/div>\n<p>When I realize how truly stupid so many people are, it discourages me about the fate of our nation. Ivermectin is for large ANIMALS and can cause all sorts of terrible side effects (including death) in humans.<\/p>\n<div class=\"reply\"><a class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=539#respond\" rel=\"nofollow\" data-commentid=\"539\" data-postid=\"2801\" data-belowelement=\"div-comment-539\" data-respondelement=\"respond\" data-replyto=\"Reply to Kathryn Rene' Griffin\" aria-label=\"Reply to Kathryn Rene' Griffin\">Reply<\/a><\/div>\n<\/div>\n<\/li>\n<li id=\"comment-3203\" class=\"comment odd alt thread-odd thread-alt depth-1 parent\">\n<div id=\"div-comment-3203\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img loading=\"lazy\" decoding=\"async\" class=\"avatar avatar-60 photo\" src=\"https:\/\/secure.gravatar.com\/avatar\/8da60489489d23f0f6874a75d42e2dea?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/8da60489489d23f0f6874a75d42e2dea?s=120&amp;d=mm&amp;r=g 2x\" alt=\"\" width=\"60\" height=\"60\" \/><cite class=\"fn\">Monte Edward<\/cite>\u00a0<span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3203\">December 10, 2023 at 7:20 am<\/a><\/div>\n<p>Think for yourself, do your own research and talk to your doctor. Ivermectin is not experimental and has been prescribed for human maladies for decades. Obviously the dosages that MDs prescribe are much lower than what veterinarians prescribe for large animals.The average dosage does not exceed 25 mg per day, depending on the weight of the person.<\/p>\n<div class=\"reply\"><a class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=3203#respond\" rel=\"nofollow\" data-commentid=\"3203\" data-postid=\"2801\" data-belowelement=\"div-comment-3203\" data-respondelement=\"respond\" data-replyto=\"Reply to Monte Edward\" aria-label=\"Reply to Monte Edward\">Reply<\/a><\/div>\n<\/div>\n<ol class=\"children\">\n<li id=\"comment-3265\" class=\"comment byuser comment-author-6512bd43d9caa6e02c990b0a82652dca bypostauthor even depth-2 parent\">\n<div id=\"div-comment-3265\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img loading=\"lazy\" decoding=\"async\" class=\"avatar avatar-60 photo\" src=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=120&amp;d=mm&amp;r=g 2x\" alt=\"\" width=\"60\" height=\"60\" \/><cite class=\"fn\">James Lawler<\/cite>\u00a0<span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3265\">December 11, 2023 at 8:20 am<\/a><\/div>\n<p>Ivermectin is a great drug \u2013 just not for treating COVID-19. While a handful of studies early in the pandemic suggested that ivermectin might be helpful for the treatment of COVID, multiple large and well-executed randomized, placebo-controlled clinical trials subsequently have provided overwhelming evidence that ivermectin provides no benefit in the treatment of COVID in developed countries. I do wonder whether a high rate of co-infection with helminths (worms) in some developing countries may have contributed to the benefit in some of the early studies, because we know that COVID often results in suppression of the immune system and susceptibility to new or recurrent opportunistic infections, such as strongyloidiasis. If I were treating a COVID patient in a developing world country with a high rate of strongyloides infection, I would consider giving ivermectin concurrently with anti-viral for SARS-CoV-2 like Paxlovid or remdesivir. But the ivermectin would be treating the worms, not the COVID. For treating COVID in places where we have incredibly low rates of helminth infections, studies make it clear that ivermectin provides absolutely no benefit. If you pull all placebo-controlled RCT\u2019s from the National Library of Medicine database (PubMed), you get a good picture of the evidence. Here is a list of all these placebo-controlled, randomized controlled trials categorized by result \u2013 most of them have open access, so you can read them:<\/p>\n<p>No Evidence of Clinical Benefit<\/p>\n<p>Naggie et al \u2013 pubmed.ncbi.nlm.nih.gov\/36269852\/<\/p>\n<p>Bramante et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36070710\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36070710\/<\/a><\/p>\n<p>Reis et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35353979\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35353979\/<\/a><\/p>\n<p>Lopez-Medina et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33662102\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33662102\/<\/a><\/p>\n<p>Lim et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35179551\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35179551\/<\/a><\/p>\n<p>Vallejos et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34215210\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34215210\/<\/a><\/p>\n<p>El Shafie et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35788169\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35788169\/<\/a><\/p>\n<p>De la Rocha et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36482326\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36482326\/<\/a><\/p>\n<p>Mirahmadizedah et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35738778\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35738778\/<\/a><\/p>\n<p>Manomaipiboon et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36028897\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36028897\/<\/a><\/p>\n<p>Buonfrate et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34999239\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34999239\/<\/a><\/p>\n<p>Evidence of Virological benefit; No Clinical Benefit<\/p>\n<p>Biber et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35811080\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35811080\/<\/a><\/p>\n<p>Ahmed et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33278625\/<\/a><\/p>\n<p>Evidence of Clinical Benefit<\/p>\n<p>Shahbaznejad et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34052007\/znejad\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34052007\/znejad<\/a>\u00a0et al \u2013\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34052007\/\" rel=\"nofollow ugc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34052007\/<\/a><\/p>\n<p>As you can see, the only RCT that appeared to show clinical benefit of ivermectin was a small study from Iran, that analyzed 35 patients in the treatment (ivermectin) group. Two studies (from Bangladesh and Israel) that analyzed fewer than 70 ivermectin-treated patients showed some evidence that viral clearance was faster, but there was no clinical (symptoms or outcome) benefit. The rest of the studies, enrolling far more patients, showed no clinical benefit from ivermectin. The first two studies are quite strong, led by Duke University and University of Minnesota respectively, enrolling almost 3,000 patients between them. These studies also looked specifically at severe COVID, hospitalization, and death, which the Biber, Ahmed, and Shahbasnejad studies were not able to do. Reis et al, a 3,500 participant RCT in Brazil, also looked at hospitalization and severe COVID, again finding no benefit.<\/p>\n<p>As you can see, the clinical evidence showing no benefit from ivermectin treatment is exceptionally strong.<\/p>\n<p>Nevertheless, I have often seen the statement, \u201cWell, you don\u2019t know for sure that it doesn\u2019t work, and since the drug is safe, what\u2019s the harm?\u201d I would argue that the trials actually have proven definitively that ivermectin is not an effective treatment for COVID. However, let\u2019s say you reserve an outside chance that the drug could be helpful in some cases \u2013 why not give it? I would argue that there are three rational arguments why we should not give ivermectin.<\/p>\n<p>First, although ivermectin has a very good safety profile, that doesn\u2019t mean it never causes harm. We have extensive experience giving the drug to mostly younger and healthier patients to treat helminth infections, and it has low rates of adverse events in that population. However, many COVID patients we treat are older and higher risk, having multiple co-morbidities and long lists of outpatient medicines. We have less experience with ivermectin in this group. Even assuming we maintain a very low rate of adverse events, if we are treating millions and millions of persons, we are still going to get many (likely dozens or hundreds) rare but significant adverse events that will harm people without offering any benefit.<\/p>\n<p>Second, people who hear about the benefit and use of ivermectin will inevitably attempt to self-treat, often with formulations made for animals and not humans. These formulations may have dramatically different concentrations\/dosing and other ingredients that may be harmful. In fact, we know this has happened based upon multiple reports of ivermectin toxicity incidents from people self-treating.<\/p>\n<p>Third, and likely most importantly, seeking and receiving treatment with ivermectin probably delays or altogether eliminates therapy with drugs that we know have very good efficacy in reducing severe disease from COVID. If you get treatment with ivermectin, you are not going to get immediate treatment with Paxlovid or remdesivir. We already know that Paxlovid reduces progression to severe COVID by 90% in those who receive early treatment. Remdesivir has similar efficacy for outpatient treatment. Anything that delays or prevents this effective treatment is doing harm.<\/p>\n<p>So, the logic is pretty clear. If you have COVID, you should seek treatment, particularly if you are higher risk for severe outcome. That treatment should be Paxlovid if possible. If not, remdesivir is a good second option, and molnupiravir is probably your third choice. There might be some other adjunctive options \u2013 data on metformin is interesting. But these first three clearly have the best evidence for efficacy.<\/p>\n<p>James Lawler, MD, MPH, FIDSA<br \/>Global Center for Health Security<br \/>University of Nebraska Medical Center<\/p>\n<\/div>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; theme_builder_area=&#8221;post_content&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<ol class=\"comment-list\">\n<li class=\"comment odd alt thread-odd thread-alt depth-1 parent\" id=\"comment-3203\">\n<ol class=\"children\">\n<li class=\"comment byuser comment-author-6512bd43d9caa6e02c990b0a82652dca bypostauthor even depth-2 parent\" id=\"comment-3265\">\n<ol class=\"children\">\n<li class=\"comment odd alt depth-3 parent\" id=\"comment-3402\">\n<div id=\"div-comment-3402\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img alt=\"\" src=\"https:\/\/secure.gravatar.com\/avatar\/30c971452b08e6bdc36d55a4b0bd74ff?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/30c971452b08e6bdc36d55a4b0bd74ff?s=120&amp;d=mm&amp;r=g 2x\" class=\"avatar avatar-60 photo\" height=\"60\" width=\"60\" loading=\"lazy\" decoding=\"async\" \/><cite class=\"fn\">Bill p<\/cite><span>\u00a0<\/span><span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3402\">December 13, 2023 at 11:04 am<\/a><\/div>\n<p>Now it comes out after trials that ivermectin is indeed a good treatment plan against Covid ,even better than the vaccine hmmm<\/p>\n<div class=\"reply\"><a rel=\"nofollow\" class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=3402#respond\" data-commentid=\"3402\" data-postid=\"2801\" data-belowelement=\"div-comment-3402\" data-respondelement=\"respond\" data-replyto=\"Reply to Bill p\" aria-label=\"Reply to Bill p\">Reply<\/a><\/div>\n<\/div>\n<ol class=\"children\">\n<li class=\"comment byuser comment-author-6512bd43d9caa6e02c990b0a82652dca bypostauthor even depth-4\" id=\"comment-3407\">\n<div id=\"div-comment-3407\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img alt=\"\" src=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=120&amp;d=mm&amp;r=g 2x\" class=\"avatar avatar-60 photo\" height=\"60\" width=\"60\" loading=\"lazy\" decoding=\"async\" \/><cite class=\"fn\">James Lawler<\/cite><span>\u00a0<\/span><span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3407\">December 13, 2023 at 12:54 pm<\/a><\/div>\n<p>Hi Bill,<\/p>\n<p>Please see our latest post on Ivermectin as a treatment for covid here<span>\u00a0<\/span><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/12\/11\/about-ivermectin\/\" rel=\"ugc\">https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/12\/11\/about-ivermectin\/<\/a><\/p>\n<div class=\"reply\"><a rel=\"nofollow\" class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=3407#respond\" data-commentid=\"3407\" data-postid=\"2801\" data-belowelement=\"div-comment-3407\" data-respondelement=\"respond\" data-replyto=\"Reply to James Lawler\" aria-label=\"Reply to James Lawler\">Reply<\/a><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li class=\"comment odd alt thread-even depth-1 parent\" id=\"comment-3359\">\n<div id=\"div-comment-3359\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img alt=\"\" src=\"https:\/\/secure.gravatar.com\/avatar\/3c8464b07ebea7e25691a1d081992fd3?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/3c8464b07ebea7e25691a1d081992fd3?s=120&amp;d=mm&amp;r=g 2x\" class=\"avatar avatar-60 photo\" height=\"60\" width=\"60\" loading=\"lazy\" decoding=\"async\" \/><cite class=\"fn\">Mary C Forbus<\/cite><span>\u00a0<\/span><span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3359\">December 12, 2023 at 12:41 pm<\/a><\/div>\n<p>I am shocked at this ignorance about IVM and the calculation of dosage. It\u2019s based on weight for horses and humans. IVM is the 3rd safest drug on the WHO list. Remdesivir has truly killed patients.It was never studied! The drug was given an EA anyway as was the jab. I will not call it a vaccine. You should be ashamed. Do your own research<\/p>\n<div class=\"reply\"><a rel=\"nofollow\" class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=3359#respond\" data-commentid=\"3359\" data-postid=\"2801\" data-belowelement=\"div-comment-3359\" data-respondelement=\"respond\" data-replyto=\"Reply to Mary C Forbus\" aria-label=\"Reply to Mary C Forbus\">Reply<\/a><\/div>\n<\/div>\n<ol class=\"children\">\n<li class=\"comment byuser comment-author-6512bd43d9caa6e02c990b0a82652dca bypostauthor even depth-2\" id=\"comment-3360\">\n<div id=\"div-comment-3360\" class=\"comment-body\">\n<div class=\"comment-author vcard\"><img alt=\"\" src=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=60&amp;d=mm&amp;r=g\" srcset=\"https:\/\/secure.gravatar.com\/avatar\/d8a02a8ef01bd72f520a4c9ce9e6be17?s=120&amp;d=mm&amp;r=g 2x\" class=\"avatar avatar-60 photo\" height=\"60\" width=\"60\" loading=\"lazy\" decoding=\"async\" \/><cite class=\"fn\">James Lawler<\/cite><span>\u00a0<\/span><span class=\"says\">says:<\/span><\/div>\n<div class=\"comment-meta commentmetadata\"><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3360\">December 12, 2023 at 12:48 pm<\/a><\/div>\n<p>Mary, please see our reply on this article here:<span>\u00a0<\/span><a href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3265\" rel=\"ugc\">https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/#comment-3265<\/a><\/p>\n<div class=\"reply\"><a rel=\"nofollow\" class=\"comment-reply-link\" href=\"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/03\/14\/an-ivermectin-influencer-died-now-his-followers-are-worried-about-their-own-severe-symptoms\/?replytocom=3360#respond\" data-commentid=\"3360\" data-postid=\"2801\" data-belowelement=\"div-comment-3360\" data-respondelement=\"respond\" data-replyto=\"Reply to James Lawler\" aria-label=\"Reply to James Lawler\">Reply<\/a><\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<div id=\"respond\" class=\"comment-respond\"><\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n<span class=\"et_bloom_bottom_trigger\"><\/span>","protected":false},"excerpt":{"rendered":"<p>Ivermectin?. No wonder the two gentlemen who discovered it won a NOBEL PRIZE! This drug DOES WAY MORE THAN THEY ARE TELLING US?! I double dare you to watch this because it will BLOW YOU AWAY? pic.twitter.com\/WOY1id6Hrh \u2014 Bobby D? (@robertdunlap947) July 13, 2024 An Ivermectin Influencer Died. Now His Followers Are Worried About Their [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":987533981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<blockquote class=\"twitter-tweet\" data-media-max-width=\"560\"><p dir=\"ltr\" lang=\"en\">Ivermectin?. No wonder the two gentlemen who discovered it won a NOBEL PRIZE! This drug DOES WAY MORE THAN THEY ARE TELLING US?! I double dare you to watch this because it will BLOW YOU AWAY?<br \/><a href=\"https:\/\/t.co\/WOY1id6Hrh\">pic.twitter.com\/WOY1id6Hrh<\/a><\/p><p>\u2014 Bobby D? (@robertdunlap947) <a href=\"https:\/\/twitter.com\/robertdunlap947\/status\/1812066142594220126?ref_src=twsrc%5Etfw\">July 13, 2024<\/a><\/p><\/blockquote><p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>","_et_gb_content_width":"","_eb_attr":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[11,60,28,21,7,6,10],"tags":[],"class_list":["post-987533979","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-action-steps","category-editors-choice","category-great-awakening","category-health","category-hidden-secrets","category-revelations","category-winning"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ivermectin, No Wonder the Two who Discovered it won a NOBEL PRIZE - Danella Consulting<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/danellaconsulting.net\/index.php\/2024\/07\/14\/ivermectin-no-wonder-the-two-who-discovered-it-won-a-nobel-prize\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ivermectin, No Wonder the Two who Discovered it won a NOBEL PRIZE - Danella Consulting\" \/>\n<meta property=\"og:description\" content=\"Ivermectin?. 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No wonder the two gentlemen who discovered it won a NOBEL PRIZE! This drug DOES WAY MORE THAN THEY ARE TELLING US?! I double dare you to watch this because it will BLOW YOU AWAY? pic.twitter.com\/WOY1id6Hrh \u2014 Bobby D? (@robertdunlap947) July 13, 2024 An Ivermectin Influencer Died. 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